Yes! You can add a new goal, edit an existing goal, or delete a goal you're not too fond of anymore. You can also edit the goal amount at any time.
To add or update goals, visit your creator profile and click on Edit your page button and select Advanced > Goals from the top menu.
From here, you'll be able to edit existing goals, delete them, or add new ones! Select the trashcan link to delete a goal. You'll find the option to add a new goal at the bottom of this page.